What is precise nutrition? What are the dimensions of precise nutrition?
"Precision medicine" is a very popular term at present. It develops the most ideal treatment plan according to the different genotypes, multi-omics characteristics, metabolic states and lifestyles of patients. Besides, with the arrival of the era of 'precision health' and 'precision nutrition', more urgent needs and challenges have been put forward for the research on nutrition science."

What is precise nutrition? Defined from the point of view of the application, it gives precise nutrition and health intervention to right individuals at the right time, which is the basic principle. The health status of individuals varies dynamically with age, environmental changes, and the occurrence of acute and chronic diseases. And the individual health is a relatively dynamic balance system. Repeated measurement of individual data and the establishment of individual index database are expected to monitor the changes in this dynamic balance system, so we call it personalized nutrition.
Analyze and intervene diet and lifestyle and provide health management. The first dimension of precision nutrition is diet and lifestyle analysis and intervention. For example, nutrition database of related diets, and the measurement of living habits, including exercise habits and the amount of exercise. In this dimension, in fact, diet and lifestyle are the main interventions for the concept of precision nutrition. How can we intervene human health? 

The main intervention objects are diet and lifestyle, which can be intervened through health management programs, dietary and living habits regulation, or dietary supplements and health products. The new technologies involved include: research and development of technologies based on pattern recognition, speech recognition and wearable devices, which help people understand life and motion state in a short time. Through the above analysis, we can achieve the collection of targeted data, the development of applied algorithms and the establishment of prediction model.

In this regard, BY-HEALTH is actively developing similar personalized healthy recipes, and gives advice based on the existing database, different needs of people and personalized evaluation, such as health management programs and precise diet on health products etc.
It needs to be emphasized that the research and development of precision nutrition products have been the most important thing in our research and development. On the one hand, we actively introduce new raw materials and develop new dosage forms to meet the new demands of consumers. On the other hand, we further study the functions of health products to upgrade the functions of the existing products and ensure the effective rate of the functions of health products. In fact, this is highly consistent with the precision nutrition strategy, because health products itself with clear functions and action mechanism are an important content of precision nutrition intervention.
 New physical examination technology assists precision nutrition management to become a reality. The second dimension of precision nutrition is called apparent analysis and intervention. This actually refers to the traditional physical examination results and some indicators of hospital testing. In this dimension, the personalized nutrition generally lacks indicators and methods. Some indicators used in medical detection can not be used directly in nutriology evaluation. Therefore, from the foundation to the transformation, great demands will emerge. Nutrition and health indicators are mainly used to assess the health status of individuals, and the effect of intervention is also assessed by such indicators. Therefore, the apparent type is suitable for evaluating the nutrition and health status of individuals at early stage and the effect after intervention. New technologies in this area include quick and inexpensive personalized testing methods and equipment, such as the quick check of a drop of blood. This is actually very necessary, because personalized health management can not be separated from repeated testing. If the testing methods can not keep up and you need to go to the hospital, there must be great difficulty for the future application. 
Therefore, in fact, the application and transformation of precision nutrition are related to precision medicine and testing technology, which involves the development of relevant concepts, and even the modeling of human experiment at the first and second phases. By applying the above techniques, individual health database and health standards can be established after individual testing data is obtained. Then, after the data operation for multi-indicators, personalized prediction and intervention program can be provided.
The genomics is used to unlock the "life code" to promote precise nutrition. The third dimension is genotype analysis and intervention, mainly including gene sequencing, SNP analysis of health, metabolism and disease, population cohort study, macro gene detection of intestinal population, etc... This can be used as a guide to nutrition intervention, but because the short-term effect is difficult to assess, it needs to be evaluated with the help of the second dimension, namely, the apparent data. New technologies in this dimension include related basic research, data interpretation, and analysis and prediction models.How to closely link the three dimensions of precision nutrition is also one of the difficulties. This requires some systematic algorithms, and even the field of application will involve techniques related to artificial intelligence learning. The associated effects of various dimensions still remain in academic exploration and research, but practical applications are more complex. People’ various choices and needs for food and nutrition also increase the difficulty for making precise nutrition programs. For example: individuals will make different choices on nutrients and food, and even some people may also be allergic to some food; people of different ages have different demands for nutrients, so the corresponding nutritional intervention programs and intervention emphasis will be different with different intervention effects; even from the point of view of the time for taking nutrients, the same nutrient is taken at different time points of the day, and some people may have different effects.
Dr. Zhang Xuguang said that now on the one hand the research direction of BY-HEALTH should be the personalized field, namely the research and development of precise nutrition technology, and then horizontally develop towards the concept of personalized nutrition products plus services; on the other hand, it should focus on the development strategy of product itself, including innovative research and development of new functions, for example, based on the progress made by the academic community in the study of platelet functions, we are currently developing the health food "maintaining healthy blood flow" by introducing "natural aspirin", namely "fruitflow" from Europe"(it has the functions of maintaining normal platelet aggregation and healthy blood flow, recognized by the European regulations). Then in terms of the development of functional food and health food, the nutrition and functional ingredients should be reflected in the food, which is convenient for the daily and long-term consumption of consumers.

The concept of precision nutrition research of BY-HEALTH: through collaborative innovation, building a R & D ecosphere in comprehensive health industry

BY-HEALTH company has established the first domestic dried blood spot testing center for precision nutrition testing, and a comprehensive knowledge database is under construction for nutrition and health evaluation. It has set up a big data center for health indicators collection and analysis of population and individuals. In terms of the transformation of specific scientific research, we have established international platform of Production, Education & Research for several key application fields, such as precise weight loss and precise lose weight for accurate and precise blood glucose reduction, and launched a series of human experiments at the first and second phases worldwide since 2016. We are integrating resources, and actively creating a shared development and cooperation platform, in order to build an R & D ecosphere involving domestic and foreign research institutions, upstream suppliers for raw materials, downstream terminals for health product sales, health management services company, and enterprises and institutions engaged in medical equipment, testing services and health insurance. In this way, resources can be integrated more efficiently. Guided by the application of ecosphere terminal market, the original plan and goals are established in R & D ecosphere, so each partner has a clear goal to carry out collaborative innovation.
BY-HEALTH has been focusing on the concept of comprehensive health. In the global layout, it has invested more than ten companies, mostly in the field of comprehensive health. Besides, the other two overseas funds are concerned about life science and artificial intelligence.
In order to improve the level of scientific research and create high-quality products and services, in recent years, BY-HEALTH has sped up the cooperation with the international authoritative research institutions, and signed global strategic cooperation agreements with Rowett Nutrition and Health Institute of the University of Aberdeen, Britain, Holland Institute of Applied Sciences, New Zealand Fonterra Co-operative Group, Germany BASF, Holland DSM, France Naturex, Italy Indena and other institutions and enterprises.